Endocrine Abstracts

We have shown that Type I IFN paradoxically inhibits autoimmune diabetes in the NOD mouse and BB rat. We assessed the structure function relationship and potential mechanism of this interferon action by determining: (1) the diabetes sparing effect of several type 1 IFNs: recombinant human IFN-A/D bgl 11 (rIFN-alpha), rIFN-alphaB/D, rIFN-alpha-consensus (CIFN), IFN-taumod1 in NOD mice (2) the effect of IFN-tau administration in IL-4 KO and IFN-gamma KO NOD mice (3) the effect o...